Control of kidney 25-hydroxyvitamin D3 metabolism. Strontium and the involvement of parathyroid hormone. |
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Authors: | J L Omdahl |
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Institution: | Biochemistry Department, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 USA |
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Abstract: | The action of parathyroid extract (PTE) on the renal metabolism of 25-hydroxyvitamin D3 (25-OHD3) was evaluated in rat models for strontium rickets and hypoparathyroidism. PTE elevated the production of 1α,25-(OH)2D3 and suppressed the synthesis of 24,25-(OH)2D3 in both animal models. Part of strontium's action in suppressing 1α,25-(OH)2D3 and stimulating 24,25-(OH)2D3 synthesis in strontium rickets appears to involve a decrease in parathyroid hormone (PTH) secretion and/or action. Calcitonin (CT) was not implicated in the cation's action. Thyroparathyroidectomized rats showed a low level of 1α,25-(OH)2D3 production which increased four- to eightfold following chronic PTE treatment. PTH appears to be the major calcium regulatory hormone involved in modulation of renal 25-OHD3 metabolism. |
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