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Substituted 2-aminopyridines as inhibitors of nitric oxide synthases |
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| Authors: | Hagmann W K Caldwell C G Chen P Durette P L Esser C K Lanza T J Kopka I E Guthikonda R Shah S K MacCoss M Chabin R M Fletcher D Grant S K Green B G Humes J L Kelly T M Luell S Meurer R Moore V Pacholok S G Pavia T Williams H R Wong K K |
| Affiliation: | Department of Medicinal Chemistry, Merck Research Laboratories Rahway, NJ 07065, USA. william_hagmann@merck.com |
| Abstract: | A series of substituted 2-aminopyridines was prepared and evaluated as inhibitors of human nitric oxide synthases (NOS). 4,6-Disubstitution enhanced both potency and specificity for the inducible NOS with the most potent compound having an IC50 of 28 nM. |
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