Estimating European admixture in African Americans by using microsatellites and a microsatellite haplotype (CD4/Alu) |
| |
| Authors: | G Destro-Bisol Riccardo Maviglia Alessandra Caglià Ilaria Boschi Gabriella Spedini Vincenzo Pascali Andrew Clark Sarah Tishkoff |
| |
| Institution: | (1) Department of Animal and Human Biology, University “La Sapienza”, P.le A. Moro 5, 00185 Roma, Italia Tel./Fax: 0039 6 4991 2273 e-mail: destrobisol@axrma.uniroma1.it, IT;(2) Institute of Legal Medicine, Catholic University of Rome, Italy, IT;(3) Forensic Biology Department, University of Verona, Italy, IT;(4) Institute of Molecular Evolutionary Genetics, Department of Biology, Pennsylvania State University, University Park, PA, USA, US |
| |
| Abstract: | We have analyzed 10 unlinked microsatellites and a linked Alu deletion polymorphism at the CD4 locus in an African American population sample from Chicago (USA). Heterozygosity estimates
at the microsatellite loci range from 0.727±0.025 (D3S1358) to 0.873±0.017 (D18S51), with an average of 0.794±0.016. These
values are comparable to or higher than those reported for Europeans, with only one exception (D3S1358). The CD4/Alu haplotypic diversity (0.887±0.012) is comparable to diversity levels observed in sub-Saharan African populations and is higher
than the diversity levels reported in European populations. No consistent pattern of within, between, or multi-locus deviations
from Hardy-Weinberg expectations is observed, suggesting a low sub-heterogeneity within the sampled population. We have applied
a maximum likelihood method and estimated the proportion of European admixture to the African American gene pool to be 0.26±0.02.
The narrow confidence interval indicates that allele frequency data from multiple microsatellite loci, whether analyzed independently
or as haplotypes, are particularly useful for estimating genetic admixture.
Received: 9 September 1998 / Accepted: 3 November 1998 |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
