Antibacterial activity of lyase-depolymerized products of alginate |
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| Authors: | Email author" target="_blank">Xiaoke?HuEmail author Xiaolu?Jiang Jun?Gong Hueymin?Hwang Yan?Liu Huashi?Guan |
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| Institution: | (1) Department of Food Engineering, Laboratory of Applied Microbiology, P.R. China;(2) Laboratory of Protozoology, Ocean University of China, Qingdao, P.R. China;(3) Biology Department, Jackson State University Jackson, Mississippi, USA |
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| Abstract: | A series of mannuronic acid (M-block) and guluronic acid (G-block) fractions (M1–M5 and G1–G5) with different molecular weights were obtained by lyase depolymerization of alginate and evaluated for in vitro antibacterial activity against 19 bacterial strains. The antibacterial data revealed that both types of fractions generally showed activity against certain tested bacteria, whereas M-block fractions showed broader spectra and more potent inhibition than G-block fractions. Among these fractions, M3 (molecular weight 4.235 kDa) exhibited the broadest spectrum of inhibition and high inhibitory activity against Escherichia coli (minimal inhibitory concentration, MIC = 0.312 μg mL−1), Salmonella paratyphi B (MIC = 0.225 μg mL−1), Staphylococcus aureus (MIC = 0.016 μg mL−1) and Bacillus subtilis (MIC = 0.325 μg mL−1). |
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| Keywords: | alginate depolymerization antibacterial activity mannuronic and guluronic acids minimal inhibitory concentration |
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