7-Deoxy-desulfo-cylindrospermopsin and 7-deoxy-desulfo-12-acetylcylindrospermopsin: Two new cylindrospermopsin analogs isolated from a Thai strain of Cylindrospermopsis raciborskii |
| |
| Institution: | 1. Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China;2. Department of Chemistry, University of British Columbia, Vancouver, BC, Canada V6T 1Z1;1. Limnological Station, Institute of Plant Biology, University of Zürich, Seestrasse 187, Kilchberg CH-8802, Switzerland;2. University of Basel, Department of Chemistry, St. Johanns-Ring 19, Basel CH-4056, Switzerland;3. Research Institute for Limnology, University of Innsbruck, Mondseestrasse 9, Mondsee A-5310, Austria;1. Environmental Engineering and Science Program, University of Cincinnati, Cincinnati, OH 45221-0012, USA;2. Department of Chemistry and Biochemistry, Florida International University, Miami, FL 3319, USA;1. Doctoral Study Program of Engineering Science, Faculty of Engineering, Udayana University, Bali-80234, Indonesia;2. Mechanical Engineering of Udayana University, Jimbaran, Badung, Bali-80362, Indonesia;3. PPPTMGB “Lemigas”, Jl. Ciledug Raya Kav. 109, Jakarta Selatan 12230, Indonesia;1. Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA;2. Environmental Engineering and Science Program, University of Cincinnati, Cincinnati, OH 45221-0012, USA |
| |
| Abstract: | As environmental changes such as eutrophication lead to increased size and frequency of cyanobacterial blooms, research into the toxins produced by these blooms becomes increasingly important. One of the common toxins produced by cyanobacterial blooms is cylindrospermopsin (1), a potent inhibitor of protein synthesis. To date, only two additional analogs of cylindrospermopsin have been isolated, namely 7-epicylindrospermopsin (2) and 7-deoxy-cylindrospermopsin (3). This report details the isolation and structure determination of an additional two new analogs, 7-deoxy-desulfo-cylindrospermopsin (4) and 7-deoxy-desulfo-12-acetylcylindrospermopsin (5). These are the first new analogs of cylindrospermopsin to be reported in over a decade. Based on their structural features, it is likely that these new analogs also possess the harmful biological activities displayed by the rest of the cylindrospermopsin family. |
| |
| Keywords: | Cylindrospermopsin Cyanobacteria HAB |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
