Antioxidant metabolites from marine alga-derived fungus Aspergillus wentii EN-48 |
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Institution: | 1. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, PR China;2. State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology, AMMS, Beijing 100850, PR China;3. Novozymes (China) Investment Co. Ltd China Headquarters, 14 Xinli Road, Shangdi Zone, Haidian District, Beijing 100085, PR China;4. University of Chinese Academy of Sciences, Beijing 100049, PR China |
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Abstract: | Eight secondary metabolites (1–8) including a new seco-anthraquinone (wentiquinone C, 1) and a new benzamide derivative (methyl 4-(3,4-dihydroxybenzamido)butanoate, 2), as well as three other derivatives (4, 7, and 8) that were isolated from natural source for the first time, were characterized from the EtOAc extracts of the marine alga-derived endophytic fungus Aspergillus wentii EN-48. The structures of the isolated compounds were elucidated on the basis of 1D and 2D NMR experiments. Each of the isolated compounds was evaluated for α,α-diphenyl-picrylhydrazyl (DPPH) radical scavenging activity, and some of them showed potent activities with IC50 values ranging from 5.2 to 99.4 μg/mL, compared to the positive control, butylated hydroxytoluene (BHT), with an IC50 of 36.9 μg/mL. |
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Keywords: | Marine alga-derived fungus Secondary metabolites Antioxidant activity |
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