Cytotoxic 7S-oxindole alkaloids from Gardneria multiflora |
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| Affiliation: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;2. University of Chinese Academy of Sciences, Beijing 100049, China;3. School of Public Health, Kunming Medical University, Kunming 650500, China;4. College of Horticulture and Landscape, Yunnan Agricultural University, Kunming 650201, China;1. Laboratory of Environmental and Applied Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, Box 183, Dschang, Cameroon;2. School of Science and Technology, Chemistry Division, University of Camerino, Via S. Agostino 1, I-62032 Camerino, Italy;3. Laboratoire de Pharmacognosie, UFR des Sciences de Santé (Pharmacie), EA 4267 (FDE/UFC), Université de Bourgogne, 7, Boulevard Jeanne d’Arc, BP 87900, 21079 Dijon Cedex, France;4. School of Pharmacy, Physiology Division, University of Camerino, Via Gentile III da Varano, I-62032 Camerino, Italy;1. Faculty of Pharmacy, Umm Al-Qura University, Makka, Saudi Arabia;2. Faculty of Pharmacy (Girls), Al-Azhar University, Nasr-City, Cairo, Egypt;3. Faculty of Pharmacy, Egyptian-Russian University, Cairo, Egypt;4. National Organization for Drug Control and Research, Dokki, P.O. 29, Cairo, Egypt;1. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People''s Republic of China;2. JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University, Guangzhou 510632, People''s Republic of China;3. College of Pharmacy, Wannan Medical College, Wuhu 241000, People''s Republic of China;1. Department of Chemistry, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya;2. Institut für Chemie, Universität Potsdam, Karl-Liebknecht-Str. 24-25, D-14476 Potsdam, Germany;3. Global Emerging Infections Surveillance (GEIS) Program, United States Army Medical Research Unit-Kenya (USAMRU-K), Kenya Medical Research Institute (KEMRI) – Walter Reed Project, Kisumu and Nairobi, Kenya |
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| Abstract: | Seven new oxindole alkaloids, gardmutines A–F (1–6) and 18-hydroxy-chitosenine (7), along with 15 known alkaloids, were isolated from the aerial parts of Gardneria multiflora Makino. The structures of the alkaloids were established by spectroscopic methods. Alkaloids 1–6 are the first Gardneria alkaloids possessing a 7S configuration. Gardmutines D and E were cytotoxic to HeLa, MCF-7 breast, and SW-480 colon cancer cell lines. |
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| Keywords: | Structure elucidation Cytotoxicity |
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