Enantiomeric chromones from Harrisonia perforata |
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| Institution: | 1. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China;2. Department of Medicinal Chemistry and Pharmacognosy, and WHO Collaborating Center for Traditional Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA;1. College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea;2. School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 712-749, Republic of Korea;1. Key Laboratory of Plants Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing South Road 40-1, Urumqi 830011, Xinjiang, PR China;2. S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashken, Uzbekistan;3. State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, PR China;4. University of Chinese Academy of Sciences, Beijing 100039, PR China;1. Queen Mary School, Nanchang University, Nanchang, Jiangxi, 330031, China;2. National Engineering Research Center for Bioengineering Drugs and Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi, 330031, PR China |
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| Abstract: | Six new chromones (1–3 and 7–9), along with 10 known ones, were isolated from the ethanol extract of Harrisonia perforata. The structures of the new compounds were elucidated by extensive spectroscopic and single crystal X-ray diffraction analyses. Compounds 1–3 and 8–9 are all racemates, and the corresponding enantiomers (+)-1/2/3/8/9 and (−)-1/2/3/8/9] were obtained by chiral HPLC separation, respectively. The absolute configuration of (+)-1 was deduced by Mosher's method. |
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| Keywords: | Prenylated chromone Enantiomer |
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