Two tetrahydroisoquinoline alkaloids from the fruit of Averrhoa carambola |
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| Institution: | 1. Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;2. University of Chinese Academy of Sciences, Beijing 100049, China;1. Jiangsu Kanion Pharmaceutical Co. Ltd., 58 South Haichang Road, Lianyungang 222001, People''s Republic of China;2. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, People''s Republic of China;1. Department of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, 1370 Sankyuk-dong, Taegu 702-701, Republic of Korea;2. Department of Chemistry, Shaheed Benazir Bhutto University, Sheringal, Dir (Upper), Khyber Pakhtunkhwa, Pakistan;1. College of Food Science and Engineering, Hainan University, Haikou, 570228, PR China;2. South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, PR China;3. Environment and Plant Protection Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, PR China;4. Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Haikou, 570228, PR China |
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| Abstract: | The fruit of Averrhoa carambola, commonly known as star fruit or carambola, is popular in Southeast Asia and China. Two new tetrahydroisoquinoline alkaloids, (1R*,3S*)-1-(5-hydroxymethylfuran-2-yl)-3-carboxy-6-hydroxy-8-methoxyl-1,2,3,4-tetrahydroisoquinoline (1) and (1S*,3S*)-1-methyl-3-carboxy-6-hydroxy-8-methyoxyl-1,2,3,4-tetrahydroisoquinoline (2), were isolated from the fruit, along with vanillic acid (3), ferulic acid (4), 8,9,10-trihydroxythymol (5), and arjunolic acid (6). Their structures were elucidated by spectroscopic method. Compounds 1, 2, and 5 showed weak ferric reducing antioxidant potency (FRAP) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. |
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| Keywords: | Star fruit Tetrahydroisoquinoline alkaloids Antioxidant activity |
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