Steroidal saponins from the leaves of Cordyline fruticosa (L.) A. Chev. and their cytotoxic and antimicrobial activity |
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| Affiliation: | 1. School of Biological Sciences, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya;2. Department of Chemistry, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya;1. Department of Oriental Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 02447, South Korea;2. Department of Chemistry, College of Natural Sciences, Salale University, Fitche, P. O. Box 245, Ethiopia;3. Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 02447, South Korea;1. Beijing Institute of Radiation Medicine, Beijing 100850, China;2. Institute of Chemical Defense, Beijing 102205, China;3. Humanwell Healthcare Group Co., Ltd, Wuhan 430075, China;4. Guanganmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China;5. Beijing Institute of Disease Prevention and Control, 100071, China;1. Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz 55128, Germany;2. Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon;3. Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon |
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| Abstract: | Three new steroidal saponins, spirosta-5,25(27)-diene-1β,3β-diol-1-O-α-l-rhamnopyranosyl-(1→2)-β-d-fucopyranoside (fruticoside H) 1, 5α-spirost-25(27)-ene-1β,3β-diol-1-O-α-l-rhamnopyranosyl-(1→2)-(4-O-sulfo)-β-d-fucopyranoside (fruticoside I) 2, and (22S)-cholest-5-ene-1β,3β,16β,22-tetrol 1-O-β-galactopyranosyl-16-O-α-l-rhamnopyranoside (fruticoside J) 3, together with the known quercetin 3-O-β-d-glucopyranoside, quercetin 3-O-[6-trans-p-coumaroyl]-β-d-glucopyranoside, quercetin 3-rutinoside, apigenin 8-C-β-d-glucopyranoside and farrerol, were isolated from the leaves of Cordyline fruticosa. Their structures were elucidated by spectroscopic techniques (1H NMR, 13C NMR, HSQC, 1H–1H COSY, HMBC, TOCSY, NOESY), mass spectrometry (HRESIMS, Tandem MS–MS), chemical methods and by comparison with published data. Compounds 1 and 2 showed moderate cytotoxic activity against MDA-MB 231 human breast adenocarcinoma cell line, HCT 116 human colon carcinoma cell line, and A375 human malignant melanoma cell line, while compound 3 was not active. Compound 2 also showed a moderate antibacterial activity against the Gram-positive Enterococcus faecalis. |
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| Keywords: | Agavaceae Steroidal saponins Biological activity |
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