A new nortriterpenoid from the fruiting bodies of Ganoderma tropicum |
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| Affiliation: | 1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People''s Republic of China;2. Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, Medical University of South Carolina, Charleston, SC 29425, United States;3. Department of BioMolecular Sciences, Division of Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, MS 38677-1848, United States;4. Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, United States;5. Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, United States;6. Department of BioMolecular Sciences, Division of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, MS 38677-1848, United States;1. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China;2. Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou 510006, China |
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| Abstract: | Ganoderma tropicum has been widely used by the local folks for coronary heart disease treatment, liver protection, and sleep aid. In order to discover natural active components and tap the medical potential of G. tropicum, the chemical investigation of its fruiting bodies was carried out. This study led to the isolation of a new nortriterpenoid named 26-nor-11,23-dioxo-5α-lanost-8-en-3β,7β,15α,25-tetrol (1) and a known nortriterpenoid lucidone D (2). The structure of the new nortriterpenoid was elucidated by spectroscopic techniques including UV, IR, MS, 1D and 2D NMR spectroscopy. |
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| Keywords: | Ganodermataceae Nortriterpenoid AChE inhibitory activity |
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