Phenolic amides from the leaves of Nicotiana tabacum and their anti-tobacco mosaic virus activities |
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| Institution: | 1. Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, PR China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China;1. College of Pharmacy, Dalian Medical University, Dalian 116044, China;2. Department of Oncology, No. 3 People''s Hospital, Affiliated with Shanghai Jiao-Tong University School of Medicine, Shanghai, China;3. Chinese People''s Liberation Army 210 Hospital, Dalian 116021, China;1. Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt;2. Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt;3. Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;4. Naturalis Biodiversity Center, Department of Marine Zoology, P.O.Box 9517, 2300 RA Leiden, The Netherlands;1. Department of Medical Biotechnology, College of Biomedical Science, Kangwon National University, Chuncheon, Gangwon-Do 200-701, Republic of Korea;2. Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, China;3. School of Medicine, China Three Gorges University, Yichang 443002, China;1. Foodborne Toxin Detection and Prevention, Western Regional Research Center, Agricultural Research Service, United States Department of Agriculture, 800 Buchanan Street, Albany, CA 94710, United States;2. Poisonous Plant Research Laboratory, Agricultural Research Service, United States Department of Agriculture, 1150 East 1400 North, Logan, UT 84341, United States;3. Paramount Farming Company, 33141 E. Lerdo Highway, Bakersfield, CA 93308, United States;1. Department of Food Science and Nutrition, and the Korean Institute of Nutrition, Hallym University, Hallymdaehak-gil 1, Chuncheon, Gwangwon-do 24252, South Korea;2. Department of Life Science and Multidisciplinary Genome Institute, Hallym University, Hallymdaehak-gil 1, Chuncheon, Gangwon-do 24252, South Korea |
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| Abstract: | Three new phenolic amides, tabamides A–C (1–3), together with three known phenolic amides (4–6), were isolated from the leaves of Nicotiana tabacum. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compounds 1–6 were also tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compound 1 exhibited high anti-TMV activity with inhibition rate of 38.6%, which is higher than that of positive control (ningnanmycin). The other compounds also showed potential anti-TMV activity with inhibition rates in the range of 15.3–26.5%, respectively. |
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| Keywords: | Phenolic amides Tabamides A–C Anti-tobacco mosaic virus activity |
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