Four new sesquiterpene polyol esters from Celastrus angulatus |
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| Affiliation: | 1. Key Laboratory of Natural Products, Henan Academy of Science, Zhengzhou 450002, China;2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Key Laboratory of Polymorphic Drugs of Beijing, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;1. Yunnan Institute of Materia Medica, Kunming 650111, China;2. Innovation and R&D Center, Yunnan Bai Yao Group, Kunming 650111, China;3. Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation, Kunming 650111, China;1. Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China;2. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, PR China;3. Pharmaceutical Engineering Department, School of Biological Science and Technology, University of Jinan, Shandong 250022, PR China;1. Jiangsu Kanion Pharmaceutical Co. Ltd., 58 South Haichang Road, Lianyungang 222001, People''s Republic of China;2. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, People''s Republic of China;1. School of Pharmacy, Nihon University, 7-7-1, Narashinodai, Funabashi 274-8555, Chiba, Japan;2. Graduate School of Pharmaceutical Sciences, Nagoya-City University, 3-1, Tanabe-Dori, Mizuho-ku, Nagoya 467-8603, Aichi, Japan;3. School of Pharmacy, China Medical University, No. 91, Hsueh-Shih R., Taichung 40402, Taiwan;4. Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Kumamoto 860-8556, Kumamoto, Japan |
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| Abstract: | Celastrus species, such as Celastrus angulatus, has been demonstrated to be very rich in natural sesquiterpene polyol esters sharing the β-dihydroagarofuran skeleton, some of which showed various biological activities. In this paper, four new sesquiterpene polyol esters, named as angulatins K-N (1–4), along with three known ones, 1β-acetoxy-9β-benzoxy-4α, 6α-dihydroxy-8α, 15-diisobutanoyloxy-2β-(α-methyl)-butanoyloxy-β-dihydroagarofuran, angulatin A, and celangulin III, were isolated from the root bark of C. angulatus. The structures of the new compounds were elucidated by extensive spectroscopic methods, mainly including HR-MS and 1D and 2D NMR techniques. |
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| Keywords: | Sesquiterpene polyol esters Angulatins K-N |
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