Isopimarane diterpenes and flavan derivatives from the twigs of Caesalpinia furfuracea |
| |
| Affiliation: | 1. Natural Products Research Laboratory, School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand;2. School of Science, University of Phayao, Phayao 56000, Thailand;3. Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand;1. Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands;2. Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, The Netherlands;3. Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India;4. Department of Pediatric Pulmonology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands;1. Laboratorio de Química Computacional, Centro de Química, Instituto Venezolano de Investigaciones Científicas, Carretera Panamericana Km 11, Altos de Pipe, Caracas, Venezuela;2. Gerencia Departamental de Investigación Estratégica RIIE, INTEVEP, Los Teques, Estado Miranda, Apartado 76343, Caracas 1070-A, Venezuela;3. Laboratorio de Química Inorgánica Teórica (LQIT), Facultad Experimental de Ciencias, La Universidad del Zulia, Ap. 526, Maracaibo, Venezuela;1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, PR China;2. School of Life Sciences, Jilin Agricultural University, Changchun 130118, China;3. Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Wanning 571533, China;4. Key Laboratory of Plant Resources Conservation andUtilization, College of Hunan Province, Jishou University, Jishou 416000, China;1. Hebei TCM Formula Granule Engineering & Technology Research Center, Hebei University of Chinese Medicine, Shijiazhuang 050091, China;2. Hebei Province Center for Disease Prevention and Control, Shijiazhuang 050021, China;1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;2. Research Studio of Integration of Traditional and Western Medicine, First Hospital, Peking University, Beijing 100034, China;1. Jiangsu Kanion Pharmaceutical Co. Ltd., 58 South Haichang Road, Lianyungang 222001, People''s Republic of China;2. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, People''s Republic of China |
| |
| Abstract: | The first phytochemical investigation of Caesalpinia furfuracea twigs led to the isolation and identification of four new compounds including two isopimarane diterpenes, caesalfurfuric acids A (1) and B (2), and two flavans, (2R)-caesalflavans A (5) and B (6), together with four known compounds, 4-epi-isopimaric acid (3), methyl (E)-3-(3,4-dihydroxyphenyl)acrylate (4), (E)-resveratrol (7) and oxyresveratrol (8). Their structures were elucidated by intensive spectroscopic analysis. Compound 1 was found to exhibit antibacterial activity against MRSA SK1 with an MIC value of 16 μg/mL. |
| |
| Keywords: | Leguminosae Isopimarane diterpene Flavan derivative Antibacterial activity |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
