New 19α-hydroxyursane-type triterpenes from the leaves of Meyna spinosa (= Vangueria spinosa), Rubiaceae |
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| Institution: | 1. Department of Chemistry, Tripura University, Suryamaninagar 799022, Tripura, India;2. Department of Chemistry, Netaji Subhash Mahavidyalaya, Udaipur 799120, South Tripura, India;3. Department of Chemistry, National Institute of Technology, Agartala, Jirania 799055, Tripura, India;1. Université Paris-Sud, UMR 8076, Chimiothérapie Antiparasitaire, Faculté de Pharmacie, 5, rue Jean-Baptiste-Clément, 92296 Châtenay-Malabry, France;2. Université Paris-Sud, Groupe Chimie Analytique Paris-Sud, EA 4041, Faculté de Pharmacie, 5, rue Jean-Baptiste-Clément, 92296 Châtenay-Malabry, France;1. Faculty of Pharmacy, Umm Al-Qura University, Makka, Saudi Arabia;2. Faculty of Pharmacy (Girls), Al-Azhar University, Nasr-City, Cairo, Egypt;3. Faculty of Pharmacy, Egyptian-Russian University, Cairo, Egypt;4. National Organization for Drug Control and Research, Dokki, P.O. 29, Cairo, Egypt;1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, PR China;2. Dalian Polytechnic University, Dalian 116034, Liaoning, PR China;1. School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, PR China;2. Department of Chemical Engineering, Kunming Metallurgy School, Kunming 650031, PR China;3. School of Life Science, Yunnan Normal University, Kunming 650500, PR China;1. State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, PR China;2. Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, PR China;3. Sichuan Wan’an Dendrobe Industry Development Co., Ltd, Chengdu 610072, PR China |
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| Abstract: | Two new 19α-hydroxyursane-type triterpenes, 2α,3α,19α,24,28-pentahydroxyurs-12-ene (1) and meyanthic acid, 3β-acetoxy-2β,19α,23-trihydroxyurs-12-en-28-oic acid (2) along with one new aliphatic ester, myricyl pentadecanoate (3) and five known compounds, 19α-hydroxyasiatic acid (4), oleanolic acid (5), myricyl alcohol (6), β-sitosterol (7) and its glycoside (8) were isolated from the methanolic leaf extract of Meyna spinosa Roxb. ex Link (= Vangueria spinosa Roxb., Rubiaceae). The structures of the new compounds were elucidated on the basis of extensive spectroscopic (including 2D NMR) analysis and comparison with literature. Except oleanolic acid, isolation of known compounds was reported for the first time from this plant. |
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| Keywords: | Rubiaceae 19α-Hydroxyursane-type triterpenes |
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