Griseofulvin-producing Xylaria endophytes of Pinus strobus and Vaccinium angustifolium: evidence for a conifer-understory species endophyte ecology |
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| Institution: | 1. Department of Chemistry, Carleton University, Ottawa, ON K1S 5B6, Canada;2. Southern Crop Protection and Food Research Centre, Agriculture and Agri-Food Canada, 1391 Sandford Street, London, ON N5V 4T3, Canada;3. Department of Chemistry and Chemical Biology, McMaster University, Hamilton, ON L8S 4M1, Canada;1. Earth and Environmental Science Department, Acadia University, Wolfville, NS, B4P 2R6, Canada;2. Department of Biology, Acadia University, Wolfville, NS, B4P 2R6, Canada;3. Nova Scotia Department of Environment, Protected Areas Branch, Canada;4. Chemistry Department, Acadia University, Wolfville, NS, B4P 2R6, Canada;1. Pharmacy Department, Faculty of Natural and Exact Sciences, University of Oriente, Ave. Patricio Lumumba s/n, Reparto Jiménez, Santiago de Cuba, 5, CP 90 500, Cuba;2. Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium;3. Centre of Studies for Industrial Biotechnology, University of Oriente, Ave. Patricio Lumumba s/n, Reparto Jiménez, Santiago de Cuba, 5, CP 90 500, Cuba;4. Laboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium;1. Institute of Fungus Resources, Department of Ecology, College of Life Sciences, Guizhou University, Guiyang, China;2. Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Collaborative Innovation Center for Mountain Ecology & Agro-Bioengineering (CICMEAB), College of Life Sciences/Institute of Agro-bioengineering, Guizhou University, Guiyang, 550025, Guizhou Province, China;3. Department of Microbiology, Guiyang College of Traditional Chinese Medicine, Guiyang, China;4. Engineering Research Center of Industrial Microbiology, Ministry of Education, Fujian Normal University, Fuzhou, China |
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| Abstract: | During three decades of research on conifer endophytes of the Acadian forest, numerous insights have been gained in conifer-fungal ecology and secondary metabolite production. Recently, we have explored endophyte assemblages of understory plants commonly occurring with pine. Here we report for the first time the production of the potent antifungal compound griseofulvin by a fungal endophyte isolated from eastern white pine (Pinus strobus) needles and lowbush blueberry (Vaccinium angustifolium) stems from the Acadian forest of New Brunswick and Nova Scotia, Canada. Maximum likelihood phylogenetic analysis has placed the endophyte strains as an undescribed Xylaria sp. Our study highlights the complexity of endophyte-host lifecycles and points to the existence of a pine-blueberry ecotype. Aside from griseofulvin, piliformic acid was isolated from one of the pine endophytes. This compound has been reported from Xylaria and related species but not from Penicillium species known to produce griseofulvin. |
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| Keywords: | Endophyte Griseofulvin Piliformic acid |
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