Chromones from the stems of Cassia fistula and their anti-tobacco mosaic virus activities |
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| Institution: | 1. College of Resource and Environment, Yuxi Normal University, Yuxi 653100, PR China;2. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, PR China;1. Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China;2. Department of Pharmacy, Sun Yat-sen University cancer center, Guangzhou 510060, PR China;3. Department of Pharmacology, School of Medicine, Jishou University, Jishou, PR China;4. National and Local United Engineering Laboratory of Druggability and New Drugs Evaluation, Guangzhou 510006, PR China;1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;2. University of Chinese Academy of Sciences, Beijing 100049, China;3. School of Public Health, Kunming Medical University, Kunming 650500, China;4. College of Horticulture and Landscape, Yunnan Agricultural University, Kunming 650201, China;1. Department of Reparative and Reconstructive Surgery, Linyi People''s Hospital, Linyi 276003, Shandong, China;2. Department of Traditional Chinese Medicine, Linyi People''s Hospital, Linyi 276003, Shandong, China;3. Department of Stomatology, Linyi People''s Hospital, Linyi 276003, Shandong, China;1. Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China;2. Pharmaceutical Engineering Department, School of Biological Science and Technology, University of Jinan, Jinan 250022, PR China;3. Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China;1. Center for Natural Products Research, Chengdu Institute of Biology of the Chinese Academy of Sciences, Chengdu 610041, People''s Republic of China;2. University of the Chinese Academy of Sciences, Beijing 10049, People''s Republic of China |
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| Abstract: | Three new chromones, 5-methoxy-2,2-dimethyl-7-(2-oxopropyl)-2,3-dihydrochromen-4-one (1), 5-methoxy-2,2-dimethyl-8-(2-oxopropyl)-2,3-dihydrochromen-4-one (2), and 1-(3,4-dihydro-5-methoxy-2,2-dimethyl-2H-chromen-7-yl)propan-2-one (3), together with four known chromones (4–7) were isolated from the stems of Cassia fistula. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compounds 1–5 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compound 5 exhibited high anti-TMV activity with inhibition rate of 30.8% at a concentration of 20 μM. The other compounds also exhibited potential anti-TMV activities with inhibition rates in the range of 15.6–22.1% at the same concentration. |
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| Keywords: | Chromones Anti-tobacco mosaic virus activity |
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