A locus on the X Chromosome is linked to body length in mice |
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| Authors: | A V Lembertas J S Fisler C H Warden P -Z Wen Y -R Xia A J Lusis |
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| Institution: | (1) Department of Medicine, Department of Microbiology and Molecular Genetics, and Molecular Biology Institute, University of California, Los Angeles, California 90095-1679, USA, US |
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| Abstract: | Linkage between body length (anus to nose (AN) length) and three markers on the mouse X Chromosome was found in an interspecific
backcross ((C57BL/6J×Mus spretus) F1 ×C57BL/6J), designated BSB. A cross of 409 mice were scored for 148 genetic markers distributed on all chromosomes except the Y Chromosome.
Statistical analysis revealed highly significant linkage (LOD score 5.5) between body length and a locus in the middle portion
of the X Chromosome, the nearest markers being the microsatellite marker DXMit73 and a farnesyl pyrophosphate locus (Fpsl9) 3.1 cM proximal to DXMit73. The locus explains 10% of the variance in AN length and affects both males and females to about the same extent.
Received: 17 April 1995 / Accepted: 13 October 1995 |
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