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Repair of DNA alkylation adducts in mammalian cells |
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| Authors: | R Montesano R Becker J Hall A Likhachev S H Lu D Umbenhauer C P Wild |
| Institution: | 1. Unit of Mechanisms of Carcinogenesis, International Agency for Research on Cancer, 150, cours Albert Thomas, 69372 Lyon Cedex 08, France |
| Abstract: | Carcinogenic alkylating agents, including nitrosamines, are able to alkylate DNA at various sites. This review presents evidence of the high degree of specificity in the type of DNA damage induced by various N-nitroso compounds and in the DNA repair processes among tissues or cells of different species. The O6-alkylguanine DNA alkyltransferase activity in various human and rodent tissues is discussed as well as the detection of O6-methylguanine in human DNA, using monoclonal antibodies and radioimmunoassay. The relevance of these findings to the mechanisms of cancer induction by nitrosamines is discussed. |
| Keywords: | nitrosamines réparation de l'ADN cancérogenèse nitrosamines DNA repair carcinogenesis 7-meG 7-methylguanine DMN dimethylnitrosamine DEN diethylnitrosamine PC parenchymal NPC non parenchymal |
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