Eradication of <Emphasis Type="Italic">Salmonella</Emphasis> Typhimurium infection in a murine model of typhoid fever with the combination of probiotic <Emphasis Type="Italic">Lactobacillus fermentum</Emphasis> ME-3 and ofloxacin |
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| Authors: | Kai Truusalu Raik-Hiio Mikelsaar Paul Naaber Tõnis Karki Tiiu Kullisaar Mihkel Zilmer Marika Mikelsaar |
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| Institution: | (1) Department of Microbiology, University of Tartu, Estonia;(2) Department of Biochemistry, University of Tartu, Estonia;(3) Department of Medical Microbiology, Stavanger University Hospital, Norway |
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| Abstract: | Background The aim of the study was to detect whether in experimental Salmonella enterica Typhimurium infection the probiotic Lactobacillus fermentum ME-3 in combination with fluoroquinolone therapy would eradicate S. Typhimurium, prevent the development of liver and spleen granulomas and improve the indices of oxidative stress in the ileum
mucosa. |
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