A novel function for the presenilin family member <Emphasis Type="Italic">spe-4</Emphasis>: inhibition of spermatid activation in <Emphasis Type="Italic">Caenorhabditis elegans</Emphasis>. |
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Authors: | Ryoko Gosney Wei-Siang Liau Craig W LaMunyon |
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Institution: | (1) Department of Biological Science, California State Polytechnic University, Pomona, CA, USA |
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Abstract: | Background Sperm cells must regulate the timing and location of activation to maximize the likelihood of fertilization. Sperm from most
species, including the nematode Caenorhabditis elegans, activate upon encountering an external signal. Activation for C. elegans sperm occurs as spermatids undergo spermiogenesis, a profound cellular reorganization that produces a pseudopod. Spermiogenesis
is initiated by an activation signal that is transduced through a series of gene products. It is now clear that an inhibitory
pathway also operates in spermatids, preventing their premature progression to spermatozoa and resulting in fine-scale control
over the timing of activation. Here, we describe the involvement of a newly assigned member of the inhibitory pathway: spe-4, a homolog of the human presenilin gene PS1. The spe-4(hc196) allele investigated here was isolated as a suppressor of sterility of mutations in the spermiogenesis signal transduction
gene spe-27. |
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