Human palatine tonsil: a new potential tissue source of multipotent mesenchymal progenitor cells |
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| Authors: | Sasa Janjanin Farida Djouad Rabie M Shanti Dolores Baksh Kiran Gollapudi Drago Prgomet Lars Rackwitz Arjun S Joshi Rocky S Tuan |
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| Institution: | (1) Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Department of Health and Human Services, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA;(2) Department of Otorhinolaryngology, Head & Neck Surgery, Zagreb Clinical Hospital Center, Zagreb University School of Medicine, Kispaticeva 12, 10000 Zagreb, Croatia;(3) Howard Hughes Medical Institute-National Institutes of Health, Research Scholars Program, 1 Cloister Court, Bethesda, MD 20814-1460, USA;(4) Division of Otolaryngology – Head and Neck Surgery, George Washington University, 2150 Pennsylvania Ave. N.W., Washington, DC 20037, USA |
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| Abstract: | Introduction Mesenchymal progenitor cells (MPCs) are multipotent progenitor cells in adult tissues, for example, bone marrow (BM). Current
challenges of clinical application of BM-derived MPCs include donor site morbidity and pain as well as low cell yields associated
with an age-related decrease in cell number and differentiation potential, underscoring the need to identify alternative sources
of MPCs. Recently, MPC sources have diversified; examples include adipose, placenta, umbilicus, trabecular bone, cartilage,
and synovial tissue. In the present work, we report the presence of MPCs in human tonsillar tissue. |
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