Viral Determinants of Rotavirus Pathogenicity in Pigs: Evidence that the Fourth Gene of a Porcine Rotavirus Confers Diarrhea in the Homologous Host |
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| Authors: | Janice C Bridger Gabriele I Tauscher and Ulrich Desselberger |
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| Institution: | Department of Pathology and Infectious Diseases, The Royal Veterinary College, University of London, London NW1 0TU,1. and Clinical Microbiology and Public Health Laboratory and Division of Virology, Department of Pathology, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 2QW,2. United Kingdom |
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| Abstract: | A porcine rotavirus (prv) monoreassortant, S-F4, which carries RNA segment 4 of the pig-pathogenic variant prv 4F in the genetic background of the pig-apathogenic variant prv 4S (G. I. Tauscher and U. Desselberger, J. Virol. 71:853–857, 1997), was found to be pathogenic in gnotobiotic piglets. This indicates that RNA segment 4 of the pig-pathogenic variant prv 4F is a major determinant of pathogenicity in its homologous host. |
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