Arachidonate 5-lipoxygenase inhibitors show potent antiproliferative effects on human leukemia cell lines |
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| Authors: | T Tsukada K Nakashima S Shirakawa |
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| Institution: | 1. Department of Biochemistry, Mie University School of Medicine, Tsu, Mie 514, Japan;7. Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514, Japan;1. Centre for Social Impact, Swinburne University of Technology, Melbourne, Australia;2. Honorary Fellow at University of Melbourne, Melbourne, Australia;3. Asia Pacific Social Impact Centre, University of Melbourne, Melbourne, Australia;4. University of Melbourne, Melbourne, Australia;1. Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China;2. Research Center of Neuroscience, First Hospital of Jilin University, Changchun, 130021, China;3. Department of Anesthesiology, First Hospital of Jilin University, Changchun, 130021, China;4. Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, 130021, China;1. Centro de Investigaciones y de Estudios Avanzados del I.P.N. Unidad Querétaro, Querétaro, Querétaro, C.P. 76230, Mexico;2. Departamento de Investigación y Posgrado en Alimentos, Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Qro., 76010, Mexico;3. Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México, A.P. 1-1010, Querétaro, Qro., 76000, Mexico;4. División de Investigación y Posgrado, Facultad de Ingeniería, C. U. Cerro de las Campanas, Centro, Universidad Autónoma de Querétaro, Querétaro, C.P. 76010, Qro., Mexico;5. Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada, Instituto Politécnico Nacional, Unidad Querétaro, Cerro Blanco No. 141, Colinas del Cimatario, Querétaro, 76090, Qro., Mexico;6. Universidad del Valle de México, Campus Querétaro, Blvd. Juriquilla no. 1000 A Del. Santa Rosa Jáuregui, Querétaro, Qro., C.P. 76230, Mexico |
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| Abstract: | Cirsiliol and AA861, specific arachidonate 5-lipoxygenase inhibitors, showed potent antiproliferative effects on human leukemic cell lines K562, Molt4B and HL60. On the other hand, HeLa cells were not affected by these drugs. In the inhibitor treated and growth retarded leukemia cells, the rates of synthesis of DNA, RNA and protein were markedly decreased. These results suggested that arachidonate 5-lipoxygenase or leukotrienes would play essential roles in cellular functions of leukemic cells. |
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