Differential desensitization of somatostatin receptor subtypes in atT-20 cells |
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Authors: | Mazza Fredric C Blake Allan D |
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Institution: | Department of Biology, Seton Hall University, South Orange, NJ 07079, USA. |
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Abstract: | Nonpeptidyl agonists for the somatostatin (SRIF) receptor family have been developed. We have studied the desensitization effects for two of these agonists upon SRIF receptor function in AtT-20 cells, a neuroendocrine tumor cell, which endogenously expresses two distinct SRIF receptor, subtypes. We observe that SRIF and the nonpeptidyl, subtype selective agonists, differentially regulate SRIF receptor subtypes in the AtT-20 cell. |
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