Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs |
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| Authors: | Wang Ben B Maghami Nima Goodlin Vanessa L Smith Paul J |
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| Institution: | Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA. |
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| Abstract: | Three new analogs of UK-1 have been synthesized and their efficacies as topoisomerase II inhibitors have been determined. Results show that UK-1 and two of these analogs are catalytic inhibitors of topo II and identifies a critical structure motif necessary for enzyme inhibition. |
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