|
|||||
|
|
Short arm dicentric Y chromosome with associated statural defects in a sterile man |
|
| Authors: | Ann C Chandley P Ambros S McBeath T B Hargreave F Kilanowski G Spowart |
| Institution: | (1) MRC Clinical and Population Cytogenetics Unit, Western General Hospital, EH4 2XU Edinburgh, UK;(2) Department of Surgery (Urology), Western General Hospital, EH4 2XU Edinburgh, UK;(3) Present address: Institute of Molecular Biology, Austrian Academy of Sciences, Billrothstrasse 11, A-5020 Salzburg, Austria |
| Abstract: | Summary A short arm dicentric Y chromosome is described as the predominant cell line in a sterile man. The patient also presents with short stature. Tooth development appears normal. Only Sertoli cells are present in the seminiferous tubules. It is suggested that the function of the gene controlling spermatogenesis in Yq11 in man might be to prevent proliferation or migration of germ cells to the gonad of the early embryo. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |