Influence of iron restriction on growth and the expression of outer membrane proteins by Haemophilus influenzae and H. parainfluenzae |
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| Authors: | Paul Williams Michael RW Brown |
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| Institution: | Microbiology Research Group, Department of Pharmaceutical Sciences, Aston University, Aston Triangle, Birminghem B4 7ET, U.K. |
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| Abstract: | Abstract The growth of both Haemophilus influenzae and H. parainfluenzae was progressively inhibited in media containing increasing concentrations of the iron chelator desferrioxamine. Iron restriction had little effect on the outer-membrane (OM) protein profiles of type b or non-typable H. influenzae although replacement of haemin with protoporphyrin IX resulted in the induction of an M r 73 000 protein in the type b strains. H. parainfluenzae , however, responded to iron restriction by inducing several new proteins in the range of M r 70 000 to 86 000. |
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| Keywords: | Haemophilus influenzae H parainfluenzae iron-restriction outer membrane proteins |
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