1.Fluxome Sciences A/S, S?ltofts Plads,Lyngby,Denmark;2.Center for Microbial Biotechnology, BioCentrum-DTU,Technical University of Denmark,Lyngby,Denmark
Abstract:
Background
Genome-scale flux models are useful tools to represent and analyze microbial metabolism. In this work we reconstructed the metabolic network of the lactic acid bacteria Lactococcus lactis and developed a genome-scale flux model able to simulate and analyze network capabilities and whole-cell function under aerobic and anaerobic continuous cultures. Flux balance analysis (FBA) and minimization of metabolic adjustment (MOMA) were used as modeling frameworks.
