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The ups and downs of biological timers
Authors:Noa?Rappaport,Shay?Winter,Naama?Barkai  author-information"  >  author-information__contact u-icon-before"  >  mailto:naama.barkai@weizmann.ac.il"   title="  naama.barkai@weizmann.ac.il"   itemprop="  email"   data-track="  click"   data-track-action="  Email author"   data-track-label="  "  >Email author
Affiliation:(1) Departments of Molecular Genetics and Physics of Complex systems, Weizmann Institute of Science, Rehovot, Israel
Abstract:

Background  

The need to execute a sequence of events in an orderly and timely manner is central to many biological processes, including cell cycle progression and cell differentiation. For self-perpetuating systems, such as the cell cycle oscillator, delay times between events are defined by the network of interacting proteins that propagates the system. However, protein levels inside cells are subject to genetic and environmental fluctuations, raising the question of how reliable timing is maintained.
Keywords:
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