Essential role for p53 and caspase-9 in DNA damaging drug-induced apoptosis in neuroblastoma IMR32 cells |
| |
Authors: | Li Tai Cui Zhao-Bo Ke Xiao-Xue Tan Juan Li Fang-Fang Li Ting Wang Xiang-Wei Cui Hong-Juan |
| |
Affiliation: | The Institute of Sericulture and Systems Biology, College of Biotechnology, Southwest University, Chongqing, China. |
| |
Abstract: | Neuroblastoma is a solid tumor of the sympathetic nervous system accounting for up to 10% of pediatric cancers and 15% of cancer-related deaths. It is a useful system for investigation of stress signal-mediated apoptosis as a tumor suppression mechanism. In this study, we present evidence that p53 mediates DNA damaging drug-induced apoptosis in IMR32 cells through the caspase-9 pathway. In summary, we define a molecular pathway for mediating DNA damaging drug-induced apoptosis in human neuroblastoma IMR32 cells and suggest that inactivation of essential components of this apoptotic pathway may confer drug resistance on neuroblastoma cells. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|