The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity |
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Authors: | Yang Christine C Chen Diana Lee Siu Sylvia Walter Ludivine |
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Affiliation: | Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA. |
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Abstract: | Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging. |
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Keywords: | aging Caenorhabditis elegans fission protein DRP‐1 insulin signaling mitochondria |
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