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Effect of beta-endorphin on gastric acid secretion and serum gastrin concentration in humans |
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| Authors: | M Feldman C H Li |
| Affiliation: | 1. Medicine and Research Service, Dallas Veterans Administration Medical Center, University of Texas Health Science Center at Dallas, Dallas, TX, U.S.A.;2. Hormone Research Laboratory, University of California Center, San Francisco, CA, U.S.A. |
| Abstract: | The effect of synthetic human β-endorphin on gastric acid secretion was studied in 9 healthy subjects. Neither 2.5 mg or 15 mg β-endorphin had a significant effect on acid secretion or on serum gastrin concentration despite the fact that this dose of opiate caused a significant increase in serum prolactin concentrations. The role of endogenous opiate-like peptides on gastric secretion is discussed. |
| Keywords: | β-endorphin gastric secretion gastrin opiates prolactin receptors |
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