Section of Protein Chemistry, Laboratory of Biochemistry, National Heart, Blood and Lung Institute, NIH, Bethesda, MD 20892, USA. aog@cu.nih.gov
Abstract:
Regulatory aspects of the bacterial phosphoenolpyruvate (PEP):sugar phosphotransferase system (PTS) are reviewed. The structure and conformational stability of the first protein (enzyme I) of the PTS, as well as the requirement for enzyme I to dimerize for autophosphorylation by PEP in the presence of MgCl2 are discussed.