Design and synthesis of a potent macrocyclic 1,6-naphthyridine anti-human cytomegalovirus (HCMV) inhibitors |
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| Authors: | Falardeau Guy Lachance Hugo St-Pierre Annie Yannopoulos Constantin G Drouin Marc Bédard Jean Chan Laval |
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| Institution: | ViroChem Pharma Inc., 275 Armand-Frappier Blvd., Laval, Québec, Canada H7V 4A7. gfalardeau@virochempharma.com |
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| Abstract: | A novel class of macrocyclic 1,6-napthyridines designed to adopt the presumed bioactive conformation of anti-HCMV acyclic 1,6-napthyridines are described. Both 14- and 15-membered macrocycles were shown to be highly potent against HCMV HSV-1 and HSV-2. |
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