Analysis of knockout mice suggests a role for VGF in the control of fat storage and energy expenditure |
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| Authors: | Elizabeth Watson Samira Fargali Haruka Okamoto Masato Sadahiro Ronald E Gordon Tandra Chakraborty Mark W Sleeman Stephen R Salton |
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| Institution: | (1) Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA;(2) Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA;(3) Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA;(4) Biology Department, Adelphi University, Garden City, NY, USA;(5) Department of Geriatrics, Mount Sinai School of Medicine, New York, NY, USA |
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| Abstract: | Background Previous studies of mixed background mice have demonstrated that targeted deletion of Vgf produces a lean, hypermetabolic mouse that is resistant to diet-, lesion-, and genetically-induced obesity. To investigate
potential mechanism(s) and site(s) of action of VGF, a neuronal and endocrine secreted protein and neuropeptide precursor,
we further analyzed the metabolic phenotypes of two independent VGF knockout lines on C57Bl6 backgrounds. |
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