Chiral amino amides for the ruthenium(II)‐catalyzed asymmetric transfer hydrogenation reaction of ketones in water |
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| Authors: | Jincheng Mao Jun Guo |
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| Institution: | Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Suzhou University, Suzhou, People's Republic of China |
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| Abstract: | The chiral amino amide 3 was derived from L ‐proline and used for the RuCl2(p‐cymene)]2‐catalyzed asymmetric transfer hydrogenation of prochiral ketones performed in water. Moderate to good chemical selectivities (up to 95% yield) and enantioselectivities (up to 90% ee) were obtained in the presence of 2 mol % of TBAB (n‐Bu4NBr) as the phase transfer catalyst. Chirality, 2010. © 2009 Wiley‐Liss, Inc. |
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| Keywords: | asymmetric transfer hydrogenation ketones water enantioselectivity ruthenium |
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