A Novel Sulfated Holostane Glycoside from Sea Cucumber Holothuria leucospilota |
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| Authors: | Hua Han Wen Zhang Yang‐Hua Yi Bao‐Shu Liu Min‐Xiang Pan Xiao‐Hua Wang |
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| Affiliation: | 1. Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo‐He Road, Shanghai 200433, P.?R. China, (phone: +862165384988;2. fax: +862165483662);3. College of Animal Sciences, Zhejiang University, 268 Kai‐Xuan Road, Hangzhou 310029, Zhejiang Province, P.?R. China |
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| Abstract: | A new sulfated holostane glycoside, leucospilotaside B ( 1 ), together with the two related structurally known compounds holothurin B2 ( 2 ) and holothurin B ( 3 ), was isolated from sea cucumber Holothuria leucospilota collected from the South China Sea. The structure of 1 was elucidated by spectral analysis (1H‐, 13C‐, and 2D‐NMR, ESI‐MS, and HR‐ESI‐MS) and chemical methods. The compounds 1 – 3 possess the same disaccharide moiety, but were different in the side chains of the triterpene aglycone. Compound 1 showed significant cytotoxicities against four human tumor cell lines, HL‐60, MOLT‐4, A‐549, and BEL‐7402. |
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| Keywords: | Holothuria leucospilota Holostane glycosides Glycosides Leucospilotaside B Triterpenes Sea cucumber |
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