Study on syntheses and anticoagulant action of heparin/rare earth nano‐oxides hybrid material |
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| Authors: | Kun‐Jie Wang Hong‐Xia Li Yu‐Min Song Ni‐Na Luan Ping Xian |
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| Affiliation: | 1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China;2. College of Life Science, Tarim University, Alar Xinjiang 843300, China |
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| Abstract: | Four hybrid materials of RE2O3‐TDI‐Heparin (TDI = Toluene 2,4–diisocyanate, RE = La, Eu, Nd, Sc) were prepared by the method of graft. The materials were characterized by IR, TG, and SEM, which confirmed that the heparin was grafted on the surface of TDI modified rare earth nano‐oxides. The cell adhesion experiment and the anticoagulant experiment demonstrated that the materials have lower cell toxicity, better cell adhesion as well as better anticoagulant action. In addition, the clotting time of hybrid materials were shortened compared with the heparin. © 2010 Wiley Periodicals, Inc. Biopolymers 93: 887–892, 2010. |
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| Keywords: | heparin rare earth nano‐oxides anticoagulant cell adhesion |
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