Studies of Amyloid‐Like Fibrillogenesis through β‐Sheet‐Mediated Self‐Assembly of Short Synthetic Peptides |
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| Authors: | Anita Dutt Elinor?C Spencer Judith?A?K Howard Animesh Pramanik |
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| Institution: | 1. Department of Chemistry, University of Calcutta, 92, A.?P.?C. Road, Kolkata‐700?009, India, (phone: +91‐33‐24841647;2. fax: +91‐33‐23519755);3. Department of Chemistry, University of Durham, South Road, Durham, UK‐DH1 3LE |
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| Abstract: | Three structurally different types of small peptides, namely, i) Boc‐Ile‐Aib‐Ile‐OMe (Aib=α‐aminoisobutyric acid), ii) Boc‐Xx‐m‐aminobenzoic acid (Xx=β‐Ala and γ‐aminobutyric acid), and iii) Boc‐Xx‐m‐nitroaniline, were found to exhibit β‐sheet‐mediated fibrillogenesis in the solid state, revealed by FT‐IR, single‐crystal X‐ray diffraction, and FE‐SEM studies. Interestingly, the fibrils grown from peptides 2 and 3 were found to bind with the physiological dye Congo red, a characteristic feature of amyloid fibrils. |
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| Keywords: | Fibrillogenesis α ‐Aminoisobutyric acid (Aib) Amyloid fibrils Amino acids Peptides X‐Ray crystallography |
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