The Resurgence of Acyclic Nucleic Acids |
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| Authors: | Su Zhang Christopher Switzer John?C Chaput |
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| Institution: | 1. Center for Evolutionary Functional Genomics, The Biodesign Institute, and Department of Chemistry and Biochemistry at Arizona State University, Tempe, Arizona 85287‐5301, USA, (phone: (480)727‐0392);2. Department of Chemistry, University of California, Riverside, California 92521, USA, (phone: (951)827‐7266) |
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| Abstract: | This review examines acyclic nucleoside analogs as therapeutic agents, potential progenitor candidates to RNA, and novel building blocks for nucleic‐acid nanotechnology. Together, these areas of research provide new insights into the structural and functional properties of nucleic acids and suggest new paradigms for nucleic acid self‐assembly. |
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| Keywords: | Acyclic nucleoside analogs Nucleic acid nanotechnology Nucleic acids Self‐assembly Oligonucleotides |
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