A New Long‐Chain Alkene and Antituberculosis Constituents from the Leaves of Pourthiaea lucida |
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| Authors: | Jih‐Jung Chen Wen‐Jiou Lin Po‐Chuen Shieh Ih‐Sheng Chen Chien‐Fang Peng Ping‐Jyun Sung |
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| Institution: | 1. Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan, (phone: +886‐8‐7624002 (ext. 2827);2. fax: +886‐8‐7624002 (ext. 5064));3. Faculty of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan;4. Faculty of Biomedical Laboratory Sciences, College of Health Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan;5. National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan |
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| Abstract: | A new long‐chain alkene, dotriacont‐1‐ene ( 1 ), was isolated from the leaves of Pourthiaea lucida, together with twelve known compounds. The structure of this new compound was determined by NMR and mass‐spectrometric analyses. Among the isolated compounds, α‐tocospiro A ( 2 ), α‐tocopheryl quinone ( 4 ), and (E)‐phytol ( 5 ) exhibited antituberculosis activities (MICs ≤30 μg/ml) against Mycobacterium tuberculosis H37Rv in vitro. |
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| Keywords: | Pourthiaea lucida Dotriacont‐1‐ene α ‐Tocospiro A α ‐Tocopheryl quinone (E)‐Phytol Antituberculosis activity |
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