Enantiodiscrimination of methamphetamine by circular dichroism using a porphyrin tweezer |
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Authors: | Marcus Anderson Katie Wilcox Mike Guericke Han Chu Mark V Wilson Erin Wilson Kerry Lucas Andrea E Holmes |
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Institution: | Department of Chemistry, Doane College, Crete, Nebraska |
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Abstract: | Using exciton‐coupled circular dichroism (ECCD) spectroscopy, our lab was able to differentiate between the two enantiomers of methamphetamine using a commercially available porphyrin tweezer as an achiral host. The host–guest complex formed with (+)‐(S)‐methamphetamine produced a negative bisignate‐shaped ECCD spectrum, whereas the complex formed with (?)‐(R)‐methamphetamine produced a positive one. This sensitive technique could serve as an alternative method for the enantiodiscrimination of chiral methamphetamine, a commonly abused drug in the United States. Chirality 2010. © 2009 Wiley‐Liss, Inc. |
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Keywords: | chiral drugs enantiomers ECCD bisignate‐shaped CD spectrum color changes |
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