Prenylated Benzophenone Peroxide Derivatives from Hypericum sampsonii |
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| Authors: | Zhi Yong Xiao Yi Han Zeng Qing Mu Winnie Ka Po Shiu Simon Gibbons |
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| Affiliation: | 1. School of Pharmacy, Fudan University, Zhangheng Road 826, Zhangjiang Pudong, Shanghai 200032, P.?R. China;2. Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, WC1N?1AX, UK |
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| Abstract: | Two new prenylated benzophenone peroxide derivatives, peroxysampsones A and B ( 1 and 2 , resp.), together with a known compound, plukenetione C ( 3 ), were isolated from the roots of the Chinese medicinal plant Hypericum sampsonii, and their structures were elucidated by detailed spectral analysis. These compounds are the unusual peroxides of polyprenylated benzophenone derivatives, containing the unique caged moiety of 4,5‐dioxatetracyclo[9.3.1.19,13.01,7]hexadecane‐12,14,15‐trione. In the biological test, peroxysampsone A ( 1 ) showed comparable activity with norfloxacin against a NorA over‐expressing multidrug‐resistant (MDR) strain of Staphylococcus aureus SA‐1199B. |
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| Keywords: | Hypericum sampsonii Peroxysampsones A and B Plukenetione C Multidrug resistance (MDR) Methicillin‐resistant Staphylococcus aureus (MRSA) Staphylococcus aureus |
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