Two New Sesquiterpene Derivatives from the Tunisian Endemic Ferula tunetana Pom. |
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| Authors: | Aymen Jabrane Hichem?Ben Jannet Zine Mighri Jean‐François Mirjolet Olivier Duchamp Féthia Harzallah‐Skhiri Marie‐Aleth Lacaille‐Dubois |
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| Institution: | 1. Institut Supérieur de Biotechnologie de Monastir, Université de Monastir, 5000 Monastir, Tunisie;2. Laboratoire de Pharmacognosie, UMIB, UPRES‐EA 3660, U.F.R. des Sciences Pharmaceutiques et Biologiques, Université de Bourgogne, F‐21079 Dijon Cedex, (phone: +33‐380‐393229;3. fax: +33‐380‐393300);4. Laboratoire de Chimie des Substances Naturelles et de Synthèse Organique, Faculté des Sciences de Monastir, Université de Monastir, 5000 Monastir, Tunisie;5. Oncodesign, 20 rue Jean Mazen, BP 27627, F‐21076 Dijon Cedex |
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| Abstract: | A new sesquiterpene ester, tunetanin A ( 1 ), a new sesquiterpene coumarin, tunetacoumarin A ( 2 ), together with eight known compounds, i.e., coladin ( 3 ), coladonin ( 4 ), isosmarcandin ( 5 ), 13‐hydroxyfeselol ( 6 ), umbelliprenin ( 7 ) propiophenone ( 8 ), β‐sitosterol ( 9 ), and stigmasterol ( 10 ), were isolated from the roots of Ferula tunetana. Their structures were elucidated on the basis of extensive spectroscopic methods, including 1D‐ and 2D‐NMR experiments and MS analysis, as well as by comparison with published data. The cytotoxicity of compounds 1 – 7 towards two human colon cancer cell lines, HT‐29 and HCT 116, was evaluated. Compounds 3, 4 , and 6 showed weak cytotoxic activities. |
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| Keywords: | Ferula tunetana Sesquiterpenes Coumarins Cytotoxic activity Antitumor activity |
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