Two New Cytotoxic Disulfated Holostane Glycosides from the Sea Cucumber Pentacta quadrangularis |
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| Authors: | Hua Han Qiang‐Zhi Xu Yang‐Hua Yi Wei Gong Bing‐Hua Jiao |
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| Institution: | 1. College of Animal Sciences, Zhejiang University, 268 Kai‐Xuan Road, Hangzhou 310029, P.?R. China;2. Department of Biochemistry and Molecular Biology, Second Military Medical University, 800 Xiang‐Yin Road, Shanghai 200433, P.?R. China, (phone: +862125070306;3. fax: +862165334344);4. Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo‐He Road, Shanghai 200433, P.?R. China |
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| Abstract: | Two new disulfated triterpene glycosides, pentactasides B and C ( 1 and 2 , resp.), were isolated from the sea cucumber Pentacta quadrangularis collected from the South China Sea. Their structures were elucidated by extensive spectral analysis (2D‐NMR and MS) and chemical methods. The compounds 1 and 2 possess the same tetrasaccharide moieties with two sulfated groups, but are different in the side chains of the triterpene aglycone. Pentactasides B and C ( 1 and 2 , resp.) showed significant cytotoxicities (IC50 0.09–2.30 μM ) against different human tumor cell lines. |
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| Keywords: | Pentacta quadrangularis Triterpene glycosides Pentactasides B and C Glycosides Cytotoxic activity |
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