Enantioselective cyanoformylation of aldehydes catalyzed with solid base mediated chiral V(V) salen complexes |
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Authors: | Noor‐Ul H. Khan Santosh Agrawal Rukhsana I. Kureshy Sayed H. R. Abdi Kavita Pathak Hari C. Bajaj |
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Affiliation: | Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Bhavnagar, Gujarat, India |
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Abstract: | Polymeric and monomeric V(V) chiral salen complexes‐catalyzed enantioselective ethyl cyanoformylation of aldehydes using ethyl cyanoformate as a source of cyanide was accomplished in the presence of several basic cocatalysts viz., NaOH, KOH, basic Al2O3 and hydrotalcite. Excellent yield (>95%) of chiral ethyl cyanohydrincarbonate with high enantioselectivity up to 94% was achieved in 24–36 h when hydrotalcite was used as an additive. The polymeric catalyst 1 is more reactive than the monomeric catalyst 2 to produce chiral ethyl cyanohydrincarbonate in high optical purity. The chiral polymeric catalyst 1 and cocatalysts hydrotalcite and basic alumina used in this study were recoverable and recyclable several times with retention of its performance. Chirality, 2010. © 2009 Wiley‐Liss, Inc. |
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Keywords: | cyanoformylation V(V) salen complex solid base enantioselective aldehydes |
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