Functional reconstitution of rat liver cytochrome P-450 with mesohemin |
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| Authors: | L M Bornheim M A Correia K M Smith |
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| Institution: | 1. Department of Pharmacology University of California, San Francisco, California USA;2. The Liver Center University of California, San Francisco, California USA |
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| Abstract: | After allylisopropylacetamide-mediated "suicide" destruction of their prosthetic heme moieties, certain rat liver cytochrome P-450 isozymes can be effectively reconstituted by addition of exogenous hemin in vitro. We now report that two of these isozymes will equally accept mesohemin , a 2,4-diethyl heme-analog and result in a "meso-hemoprotein" with altered spectral but not functional characteristics. |
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