In vitro anticryptosporidial activity of dinitroaniline herbicides |
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| Authors: | Michael J. Arrowood Jan R. Mead Long-ti Xie Xiangdong You |
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| Affiliation: | Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 4770 Buford Highway NE, Atlanta, GA 30341-3724, USA; Department of Pediatrics, Emory University, Atlanta, GA 30022, USA; VA Medical Center, Decatur, GA 30033, USA |
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| Abstract: | Abstract Despite the evaluation of over 100 antimicrobial drugs, the diarrheal disease cryptosporidiosis has remained refractory to treatment. We report the evaluation of five dinitroaniline herbicides including trifluralin, profluralin, nitralin, pendimethalin, and fluchloralin for anticryptosporidial activity in an in vitro cultivation model of Cryptosporidium parvum . All five compounds exhibited significant anticryptosporidial activities with no corresponding evidence of toxicity. The most active compound was pendimethalin with an IC50 of 0.19 μM while nitralin was the least active with an IC50 of 4.5 μM. These compounds should be evaluated further in an animal model of cryptosporidiosis. |
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| Keywords: | Cryptosporidium Dinilroaniline Microtubule Herbicide In vitro assay Madin Darby canine kidney cell (MDCK cell) |
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