Increased permeability of gut mucosa in rats infected with Nippostrongylus brasiliensis. |
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Authors: | Y Nawa |
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Institution: | Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, Australia |
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Abstract: | The permeability of the gut mucosa to macromolecules has been examined in 4 different strains of rats infected with Nippostrongylus brasiliensis (N. brasiliensis). There is a marked increase in mucosal permeability during the infection. In addition, a considerable strain difference is observed in both worm burden kinetics and the kinetics of intestinal permeability. The dose-response and drug treatment experiments in outbred Wistar rats suggest that increased mueosal permeability is a function of the worm burden. However, the increased permeability is related neither to the rapid phase of worm expulsion nor to the rise in intestinal mast cell numbers. |
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Keywords: | Nippostrongylus brasiliensis mucosal permeability worm expulsion rats strain difference |
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